Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2'-nitroflavone | inhibits caspases and tumor cell growth in diverse tissues, overview | Mus musculus | |
N-carbobenzyloxy-Ile-Glu(OMe)-Thr-Asp(OMe) fluoromethyl ketone | caspase-8 inhibition inhibits apoptosis | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Mus musculus | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | apoptotic cell deathin LM3 cells is characterized by the activation of caspase-8, -9 and -3, by an increment in the expression levels of the proapoptotic protein Bax and by the release of cytochrome c to cytosol | ? | - |
? | |
additional information | Mus musculus BALB/c | apoptotic cell deathin LM3 cells is characterized by the activation of caspase-8, -9 and -3, by an increment in the expression levels of the proapoptotic protein Bax and by the release of cytochrome c to cytosol | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
Balb/c mice | - |
Mus musculus BALB/c | - |
Balb/c mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
LM3 cell | - |
Mus musculus | - |
mammary adenocarcinoma cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Ac-IETD-7-amido-4-methylcoumarin + H2O | - |
Mus musculus | Ac-IETD + 7-amino-4-methylcoumarin | - |
? | |
Ac-IETD-7-amido-4-methylcoumarin + H2O | - |
Mus musculus BALB/c | Ac-IETD + 7-amino-4-methylcoumarin | - |
? | |
additional information | apoptotic cell deathin LM3 cells is characterized by the activation of caspase-8, -9 and -3, by an increment in the expression levels of the proapoptotic protein Bax and by the release of cytochrome c to cytosol | Mus musculus | ? | - |
? | |
additional information | apoptotic cell deathin LM3 cells is characterized by the activation of caspase-8, -9 and -3, by an increment in the expression levels of the proapoptotic protein Bax and by the release of cytochrome c to cytosol | Mus musculus BALB/c | ? | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Mus musculus |